I have been working on an assisted-segmentation (a.k.a. semi-automatic segmentation) algorithm called livewire for use in the SLASH project.
Livewire is an algorithm where the user select a point and then moves the mouse and in real time it shows the "best" path between the point and the mouse. There are other implementations of this algorithm available online, many open-source. However this implementation sets itself apart with speed and quality of results.
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